Differential expression of entorhinal cortex and hippocampal subfields α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and N-methyl-D-aspartate (NMDA) receptors enhanced learning and memory of rats following administration of Centella asiatica.

Jia Hui Wong,Sangu Muthuraju,Faruque Reza,Mohd Harizal Senik,Jingli Zhang,Nor Aqilah Binti Mohd Yusuf Yeo,Huei Gau Chuang,Hasnan Jaafar,Siti Rafidah Yusof,Habsah Mohamad,Tengku Sifzizul Tengku Muhammad,Nor Hadiani Ismail, Siti Sarwana Husin,Jafri Malin Abdullah

Biomedicine & Pharmacotherapy（2019）

Cited 21|Views29

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Abstract

•Centella asiatica (CA) extract enhances learning and memory.•CA extract increases expression of AMPAR subunits GluA1 and GluA2.•CA extract increases expression of NMDAR subunit GluN2B while reduces GluN2A.•CA extract did not cause neuronal damage.

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Key words

AMPA,AMPARs,CA,CA1,CA3,EC,HPLC,MWM,NMDA,NMDARs,NORT,OFT,PBS,PFA

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