Chronic Rhinosinusitis in Elderly Patients is Associated with an Exaggerated Neutrophilic Pro-Inflammatory Response to Pathogenic Bacteria.

Justin C Morse,Ping Li,Kim A Ely,Meghan H Shilts,Todd J Wannemuehler,Li-Ching Huang,Quanhu Sheng,Naweed I Chowdhury,Rakesh K Chandra,Suman R Das,Justin H Turner

Journal of Allergy and Clinical Immunology（2019）

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摘要

Aged CRS patients have a unique inflammatory signature that corresponds to a neutrophilic pro-inflammatory response. Neutrophil-driven inflammation in aged CRS patients may be less likely to respond to corticosteroids and may be closely linked with chronic microbial infection or colonization.

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关键词

Rhinosinusitis,aging,cytokine,neutrophil,bacteria,endotype,inflammation,IL-1β

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