Chronic dysfunction of blood-brain barrier in patients with post-encephalitic/encephalopathic epilepsy.

Tomokazu Kimizu,Yukitoshi Takahashi,Taikan Oboshi,Asako Horino,Hirowo Omatsu,Takayoshi Koike,Shinsaku Yoshitomi,Tokito Yamaguchi,Hideyuki Otani,Hiroko Ikeda,Katsumi Imai,Hideo Shigematsu,Yushi Inoue

Seizure（2018）

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摘要

•PEE is recognized as drug-resistant epilepsy.•Patients with PEE have severe chronic BBB dysfunction.•PEE patients with widespread brain injury have higher seizure frequency.•Chronic BBB dysfunction contributes to refractory epilepsy in patients with PEE.

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关键词

BBB,CSF,DC,FCD,MAPK,MMP,PEE,QAlb,TGFβ

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