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Neuraxial TNF and IFN-beta co-modulate persistent allodynia in arthritic mice.

Sarah A Woller, Cody Ocheltree,Stephanie Y Wong,Anthony Bui,Yuya Fujita,Gilson Gonçalves Dos Santos,Tony L Yaksh,Maripat Corr

Brain, Behavior, and Immunity（2019）

Cited 17|Views17
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Abstract
•Male K/BxN arthritic mice display marked persistent allodynia compared to females.•TLR4 governs chronic tactile allodynia in arthritic mice.•Co-modulation of spinal TNF and IFNβ reverses allodynia but not independently.
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Key words
Toll-like receptors,Allodynia,Arthritis,Interferon,Sex differences
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