Knockdown on aPKC-ι inhibits epithelial-mesenchymal transition, migration and invasion of colorectal cancer cells through Rac1-JNK pathway.
Experimental and Molecular Pathology（2019）
Abstract
Knockdown on aPKC-ι inhibited the EMT, migration and invasion of CRC cells through suppressing of Rac1-JNK pathway. Those findings indicate that aPKC-ι may serve as a novel therapeutic target for CRC.
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Key words
Colorectal cancer,Atypical protein kinase C-ι,Epithelial-mesenchymal transition,Migration and invasion,Auranofin
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