Interleukin-1 mediates ischaemic brain injury via distinct actions on endothelial cells and cholinergic neurons.

Raymond Wong,Nikolett Lénárt,Laura Hill,Lauren Toms,Graham Coutts,Bernadett Martinecz, Eszter Császár,Gábor Nyiri,Athina Papaemmanouil,Ari Waisman,Werner Müller,Markus Schwaninger,Nancy Rothwell,Sheila Francis,Emmanuel Pinteaux,Adam Denés,Stuart M Allan

Brain, Behavior, and Immunity（2019）

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摘要

•Brain endothelial cells mediate detrimental actions of IL-1 in cerebral ischemia.•Neuronal cholinergic IL-1R1 also mediate detrimental actions of IL-1 in brain injury.•Brain endothelial IL-1 actions reduce cortical perfusion after cerebral ischemia.•Ubiquitous IL-1R1 deletion does not affect injury, suggesting compensatory mechanisms.

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