ATF4 Deficiency Promotes Intestinal Inflammation in Mice by Reducing Uptake of Glutamine and Expression of Antimicrobial Peptides.

Xiaoming Hu,Jiali Deng,Tianming Yu,Shanghai Chen,Yadong Ge,Ziheng Zhou,Yajie Guo,Hao Ying,Qiwei Zhai,Yan Chen,Feixiang Yuan,Yuguo Niu,Weigang Shu, Huimin Chen,Caiyun Ma,Zhanju Liu,Feifan Guo

Gastroenterology（2019）

引用 63|浏览38

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摘要

Levels of ATF4 are decreased in inflamed intestinal mucosa from patients with active CD or UC. In mice, ATF4 deficiency reduces glutamine uptake by intestinal epithelial cells and expression of antimicrobial peptides by decreasing transcription of Slc1a5. ATF4 might therefore be a target for the treatment of IBD.

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关键词

Gene regulation,immune response,mouse model,intestine

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