Community-Acquired Disseminated Exophiala Dermatitidis Mycosis With Necrotizing Fasciitis In Chronic Graft-Versus-Host Disease
INTERNAL MEDICINE(2019)
摘要
We herein report a case of systemic phaeohyphomycosis by Exophiala dermatitidis (E. dermatitidis) with chronic graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (HSCT). The patient had been taking oral corticosteroids for years to control the GVHD. Yeast-like fungi were identified in a blood culture, so treatment with micafungin (150 mg/day) was begun, with no improvement. The patient passed away on hospital Day 12. A sequence analysis of rRNA revealed the isolate to be E. dermatitidis. This report brings attention to an emerging mycosis of community-acquired Exophiala species infection in the very-late phase after allogenic HSCT in patients with chronic GVHD.
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关键词
Exophiala dermatitidis, chronic graft versus host disease (GVHD), phaeohyphomycosis, immunosuppressive drug, acute myeloid leukemia, necrotizing fasciitis
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