Chemokine CXCL10/CXCR3 Signaling Contributes to Neuropathic Pain in Spinal Cord and Dorsal Root Ganglia After Chronic Constriction Injury in Rats.

Yonglin Chen,Dekun Yin,Bingbing Fan,Xiang Zhu,Qiuping Chen,Yao Li,Shunxing Zhu,Rongxiang Lu,Zhongling Xu

Neuroscience Letters（2019）

Cited 31|Views4

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Abstract

•The expression and distribution of CXCL10 and CXCR3 in the SC and DRG following CCI.•Intrathecal injection of CXCR3 inhibitor AMG487 down-regulated p-ERK expression in CCI-induced neuropathic pain.•Inhibition of CXCR3 alleviated the pain hypersensitivity induced by CCI.

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Key words

Neuropathic pain,CXCL10,CXCR3,p-ERK,Chronic constriction injury (CCI)

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