Neuroprotective and antihyperalgesic effects of orexin-A in rats with painful diabetic neuropathy.

Seddigheh Niknia,Ayat Kaeidi,Mohammad Reza Hajizadeh,Mohammad Reza Mirzaei,Alireza Khoshdel,Zahra Hajializadeh,Mohammad Ali Fahmidehkar,Mehdi Mahmoodi

Neuropeptides（2019）

引用 8|浏览8

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摘要

•We evaluate the antinociceptive effects of orexin-A is painful diabetic neuropathy (PDN).•We evaluate the antiapoptotic effect of orexin-A on lumbar spinal cord of rats with PDN.•We find that orexin-A has antinociceptive effects in rats with PDN.•We find that orexin-A has antiapoptotic effect in spinal cord of rats with PDN.•Orexin-A can reduces the hyperalgesia and spinal cord neuronal apoptosis in rats with PDN.

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关键词

Diabetic neuropathy,Orexin-A,Apoptosis,Nociception,Rat

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