PEG-b-poly (carbonate)-derived nanocarrier platform with pH-responsive properties for pancreatic cancer combination therapy.

•pH-responsive nanocarriers are synthesized for pancreatic cancer.•Nanocarriers encapsulate and release Gemcitabine and GDC 0449 (an Hedgehog inhibitor).•Nanocarriers mixed stoichiometrically to obtain compartment-specific drug release.•Nanocarrier delivery suppressed proliferation of pancreatic cancer cells.•pH-responsive nanocarriers accumulated inside tumor microenvironment.