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Three new labdane-type diterpenoids from Callicarpa macrophylla Vahl.

Zhen-Hui Wang,Huan-Jun Xu,Yang-Yang Zhai,Lan-Ping Yang,Qiang Li,Mei Huang,Xing-Ying Chen,Wen-Kui Zhang,Yue-Li Meng,Qing-Ling Zhang,Chao Niu,Yan-Ru Zhang

Natural Product Research（2019）

Cited 9|Views0
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Abstract
Three new labdane-type diterpenoids, callicapene M3-M5 (1–3) were isolated from the Callicarpa macrophylla Vahl. Their structures were identified by spectroscopic method. The isolated compounds were evaluated for inhibitory activity on NO production in LPS-activated RAW 264.7 macrophage cells by using MTT assays. Compounds 1–3 showed potent inhibitory activity, with IC50 value of 48.15, 46.31 and 38.72μm respectively.
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Callicarpa macrophylla Vahl.,labdane-type diterpenoids,NO inhibition
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