Nasal allergen-neutralizing IgG 4 antibodies block IgE-mediated responses: Novel biomarker of subcutaneous grass pollen immunotherapy.

Mohamed H Shamji,Jasper Kappen,Hisham Abubakar-Waziri,Jinjin Zhang,Esther Steveling, Shelley Watchman,Lubna Kouser,Aarif Eifan,Amy Switzer,Gilda Varricchi,Gianni Marone, Natália C Couto-Francisco,Moises Calderon,Stephen R Durham

Journal of Allergy and Clinical Immunology（2019）

引用 84|浏览38

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摘要

For the first time, we show that nasal IgG-associated inhibitory activity correlate closely with the clinical response to allergen immunotherapy in allergic rhinitis with/without asthma.

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关键词

Biomarkers of allergen immunotherapy,subcutaneous immunotherapy,IgE-facilitated allergen binding,blocking antibodies,IgG4,IgA1,IgA2,allergic rhinoconjunctivitis with and without asthma

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