Base excision repair (OGG1 and XRCC1) and metabolism (PON1) gene polymorphisms act on modulation of DNA damage and immune parameters in tobacco farmers

Vivian Francilia Silva Kahl, Daniel Simon,Melissa Rosa de Souza, Vieira Henrico da Rosa,Caroline Nicolau,Fernanda R. Da Silva,Katia Kvitko,Alessandra Peres,Gilson Pires Dorneles,Cláudia Telles de Souza,Johnny Ferraz Dias, Juliana Da Silva

Mutation Research/Genetic Toxicology and Environmental Mutagenesis（2018）

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摘要

•Tobacco farmers presented elevated NPB, MN and NBUD when compared to controls.•IL-6 and TNF-α serum levels were higher for farmers, while CD4+/CD8+ was decreased.•XRCC1Arg194Trp polymorphism modulated DNA Damage.•OGG1Ser326Cys polymorphism modulated inflammatory response.•S, Cl and K were significantly increased in tobacco farmers blood samples.

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关键词

Occupational exposure,Inflammation,Micronucleus test,Pesticides,Susceptibility,OGG1

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