Acyl-ghrelin mediated lipid retention and inflammation in obesity-related Type 2 diabetes.
Molecular and Cellular Endocrinology(2019)
Abstract
Acyl-ghrelin has various peripheral effects including the potential role in mediating cellular lipid removal and macrophage polarization. Previous reports are contradictory as to how glycaemia and acyl-ghrelin mediates lipid retention and inflammation within individuals with Type 2 diabetes (T2D). Our aim was to explore acyl-ghrelin levels and ghrelin expression in relation to lipid and inflammatory markers within an ex vivo human model, biopsied visceral adipose tissue.
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Key words
Acyl-ghrelin,Type 2 diabetes,Lipid retention,Inflammation
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