Identification of schizophrenia related biological pathways across eight brain regions.

•This study provided a novel method to identify tissue specificity pathways associated with schizophrenia.•This study provided novel insight to interpret the potential effects of suspicious variants via enhancers.•Our study showed evidences that schizophrenia is a mental disorder with early brain dysplasia from a genetic standpoint.•Our results provided novel insight to the pathophysiology of schizophrenia.