Synthesis, and anti-proliferative, Pim-1 kinase inhibitors and molecular docking of thiophenes derived from estrone.
Bioorganic Chemistry(2019)
摘要
•Heterocyclization reactions of estrone were studied.•Structures of the newly synthesized products were confirmed.•Cytotoxicity, toxicity, kinase inhibition and Pim-1 kinase evaluations of the newly synthesized products.
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关键词
Estrone,Thiophene,Thiazole,Pyridine,Anti-proliferative,Pim-1 kinase inhibitors
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