Synthesis, and anti-proliferative, Pim-1 kinase inhibitors and molecular docking of thiophenes derived from estrone.

Rafat M Mohareb,Eman M Samir,Peter A Halim

Bioorganic Chemistry（2019）

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摘要

•Heterocyclization reactions of estrone were studied.•Structures of the newly synthesized products were confirmed.•Cytotoxicity, toxicity, kinase inhibition and Pim-1 kinase evaluations of the newly synthesized products.

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关键词

Estrone,Thiophene,Thiazole,Pyridine,Anti-proliferative,Pim-1 kinase inhibitors

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