Blockade of peripheral endothelin receptors abolishes heat hyperalgesia and spontaneous nociceptive behavior in a rat model of facial cancer.

•Tumor-bearing rats developed heat hyperalgesia and increased spontaneous grooming.•Peripheral blockade of endothelin receptors reduced tumor-induced heat hyperalgesia.•Peripheral blockade of endothelin receptors abolished tumor-induced spontaneous grooming.•Peripheral blockade of endothelin receptors failed to induce CPP in tumor-rats.•Peripheral endothelin receptors contribute to tumor-induced pain-like behaviors.