Exendin-4 Improves Behaviorial Deficits via GLP-1/GLP-1R Signaling following Partial Hepatectomy.

Yongjian Zhou,Zhe Li,Xuezhao Cao,Hong Ma,Paul F White,Xiaohan Xu,Yanhua Jiang,Xijia Sun,Yong Cui

Brain Research（2019）

引用 8|浏览5

暂无评分

摘要

•Surgical trauma exacerbates cognitive deficits and neuroinflammatory response in aged rats.•Surgical trauma decreases the levels of GLP-1 and GLP-1R expression.•Exendin-4 inhibits neuroinflammatory response by modulation of microglia functions.•Exendin-4 enhances the expression of p-GSK-3β (Ser9) and synaptophysin.

查看译文

关键词

Postoperative cognitive dysfunction (POCD),GLP-1/GLP-1R,Neuroinflammation,Hippocampus,Cytokines,Ageing

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要