Exendin-4 Improves Behaviorial Deficits via GLP-1/GLP-1R Signaling following Partial Hepatectomy.
Brain Research(2019)
摘要
•Surgical trauma exacerbates cognitive deficits and neuroinflammatory response in aged rats.•Surgical trauma decreases the levels of GLP-1 and GLP-1R expression.•Exendin-4 inhibits neuroinflammatory response by modulation of microglia functions.•Exendin-4 enhances the expression of p-GSK-3β (Ser9) and synaptophysin.
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关键词
Postoperative cognitive dysfunction (POCD),GLP-1/GLP-1R,Neuroinflammation,Hippocampus,Cytokines,Ageing
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