The FGF1/CPP-C chimera protein protects against intestinal adverse effects of C-ion radiotherapy without exacerbating pancreatic carcinoma.

Mitsuko Kawano,Taichi Miura,Mayumi Fujita,Sachiko Koike,Kaori Imadome,Atsuko Ishikawa,Takeshi Yasuda,Toru Imamura,Takashi Imai,Fumiaki Nakayama

Clinical and Translational Radiation Oncology（2019）

Cited 4|Views15

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Abstract

•C-ion radiotherapy is applied to pancreatic carcinoma in the abdominal cavity.•The FGF1/CPP-C chimeric protein has an intracellular signaling mode.•FGF1/CPP-C protects against C-ion-induced intestinal damage.•FGF1/CPP-C inhibits the proliferation and metastasis of pancreatic carcinoma cells.•FGF1/CPP-C may be useful for C-ion radiotherapy against pancreatic cancer.

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Key words

C-ion,CPP,FGF,FGFR,HIMAC,SOBP,TBI,TUNEL

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