Aging leads to dysfunctional innate immune responses to TLR2 and TLR4 agonists.

Kristina L Bailey,Lynette M Smith,Art J Heires,Dawn M Katafiasz,Debra J Romberger,Tricia D LeVan

Aging clinical and experimental research（2019）

引用 32|浏览23

暂无评分

摘要

With aging, circulating leukocytes produce high levels of TNFα at baseline and have inadequate responses to TLR2 and TLR4 agonists. These defects likely contribute to the increased susceptibility to sepsis in older adults.

查看译文

关键词

Aging,Sepsis,Shock,Innate immunity,TLR signaling,Inflammaging,Immunosenescence,TNFα

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要