Vitamin E intake and risk of stroke: a meta-analysis.

Findings from observational studies on the associations between vitamin E intake and stroke risk remain controversial, and the dose-response relationship between vitamin E intake and risk of stroke remains to be determined. We conducted a meta-analysis of prospective studies aiming to clarify the relationships between vitamin F, intake and risk of stroke. Relevant studies were identified by searching online databases through to June 2018. We computed summary relative risks (RR) with corresponding 95% CI. Among 3156 articles retrieved from online databases and relevant bibliographies, nine studies involving 3284 events and 220 371 participants were included in the final analyses. High dietary vitamin E intake was inversely associated with the risk of overall stroke (RR= 0.83, 95% CI 0.73, 0.94), and with the risk of stroke for individuals who were followed-up for <10 (RR =0.84, 95% CI 0.72, 0.91). There was a non-linear association between dietary vitamin E intake and stroke risk (P = 0.0249). Omission of any single study did not alter the summary result. In conclusion, this meta-analysis suggests that there is a significant inverse relationship between dietary vitamin E intake and stroke risk. This meta-analysis provides evidence that a higher dietary vitamin F, intake is associated with a lower stroke risk.