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In vitro anti-Trypanosoma cruzi activity of ternary copper(II) complexes and in vivo evaluation of the most promising complex.

Drielly A Paixão,Carla D Lopes,Zumira A Carneiro,Luana M Sousa,Leticia P de Oliveira,Norberto P Lopes,Marcos Pivatto,Joana Darc S Chaves,Mauro V de Almeida,Javier Ellena,Mariete B Moreira,Adelino V G Netto,Ronaldo J de Oliveira,Silvana Guilardi,Sérgio de Albuquerque,Wendell Guerra

Biomedicine & Pharmacotherapy（2019）

Cited 25|Views38
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Abstract
•Seven Cu(II) complexes with hydrazides and heterocyclic bases were prepared.•Six Cu(II) complexes were evaluated in vitro against T. cruzi.•Two copper complexes were more active than benznidazole.•The antichagasic activity of the most promising complex was evaluated in vivo.
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phen,bipy,dmb,2-MH,4-MH,AH,UV–vis,HRESIMS,IR,BZN,DMSO,SI,CC50,IC50,CD,ct-DNA
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