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Oral delivery of the anti-tumor necrosis factor α domain antibody, V565, results in high intestinal and fecal concentrations with minimal systemic exposure in cynomolgus monkeys.

J Scott Crowe,Kevin J Roberts,Timothy M Carlton,Luana Maggiore,Marion F Cubitt,Keith P Ray, Mary C Donnelly, John C Wahlich, Jonathan I Humphreys, Jan R Robinson, Gary A Whale,Michael R West

Drug development and industrial pharmacy（2019）

Cited 26|Views7
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Abstract
These results suggest that mini-tablets with a 24% Eudragit enteric coating are suitable for targeted release of orally delivered V565 in the intestine for topical treatment of IBD.
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Key words
Anti-TNFα,Eudragit,domain antibody,enteric,formulation,gastrointestinal,oral,pharmacokinetics
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