HIF-1α is critical for the activation of Notch signaling in neurogenesis during acute epilepsy.

•The expression of HIF-1α was found to be upregulated in acute epilepsy.•HIF-1α upregulation enhanced neurogenesis during epileptogenesis, which required the participation of Notch signaling.•HIF-1α activated Notch signaling by physically interacting NICD in epilepsy.