RUNX2 mutation impairs osteogenic differentiation of dental follicle cells.
Archives of Oral Biology（2019）
Abstract
•A novel RUNX2 mutation was detected in a CCD patient with typical clinical features.•The novel mutation was located in Runt domain and altered secondary structure of RUNX2.•Mutant RUNX2 can promote proliferation and suppress osteogenic differentiation of DFCs.
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Key words
Cleidocranial dysplasia,RUNX2 mutation,Dental follicle cells,Osteogenic differentiation,Bone remodeling
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