Molecular-docking-guided design and synthesis of new IAA-tacrine hybrids as multifunctional AChE/BChE inhibitors.

•New IAA-tacrine hybrids were synthesized as potent dual AChE/BChE inhibitors.•This series of hybrids targeted both CAS and PAS of AChE and BChE.•Compound 5e could increase the frequency of the network oscillation.•Compound 5e could decrease the duration of synchronized firing.