TARBP2 negatively regulates IFN-β production and innate antiviral response by targeting MAVS.

Ting Ling,Sheng-Na Li,Guang-Xiu Weng,Weiying Wang,Changsheng Li,Lingzhen Cao,Hua Rao,Hong-Bing Shu,Liang-Guo Xu

Molecular Immunology（2018）

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摘要

•MAVS is essential in anti-viral innate immunity.•TARBP2, acted as a component of RISC, is involved in the biogenesis of miRNA.•AGO2, as well as PAC, are both components of RISC, participate in regulating type I interferon signaling.•TARBP2 negatively regulated Sendai virus-induced IFN-β activation.

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关键词

MAVS,TARBP2,RIG-I,TRAF3,IFN-Β

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