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Altered expression of inflammasomes in Hirschsprung's disease.

Hiroki Nakamura,Anne Marie O'Donnell,Naoum Fares Marayati,Christian Tomuschat,David Coyle,Prem Puri

Pediatric surgery international（2019）

Cited 5|Views4
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Abstract
To our knowledge, this is the first study analyzing NLRP3, NLRP12, NLRC4, ASC and pro-IL-1β gene expressions in patients with HSCR. Decreased expression of NLRP3, NLRP12, NLRC4, ASC and pro-IL-1β in the aganglionic and ganglionic bowel may increase susceptibility of HSCR patients to develop HAEC.
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Key words
Enterocolitis,Hirschsprung's disease,Inflammasome
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