Palladium-Catalyzed Carbon Isotope Exchange On Aliphatic And Benzoic Acid Chlorides

An operationally simple protocol for a palladium-catalyzed (CO)-C-13 and (CO)-C-14 exchange with activated aliphatic and benzoic carbonyls is presented. Several C-13 and C-14 building blocks, natural product derivatives, and pharmaceuticals have been prepared to showcase the method for late-stage carbon isotope incorporation and its functional group compatibility.