An improved model of ethanol and nicotine co-use in female P rats: Effects of naltrexone, varenicline, and the selective nicotinic α6β2* antagonist r-bPiDI.
Drug and Alcohol Dependence（2018）
Abstract
•Levels of EtOH and nicotine intake during co-use were pharmacologically relevant.•Increasing the fixed ratio (FR) requirement for nicotine increases EtOH intake during co-use.•Naltrexone decreased EtOH and water intake, but not nicotine intake during co-use.•Varenicline and r-bPiDI decreased active and inactive lever pressing for nicotine.
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Key words
Alcohol,Nicotine,Co-use,Varenicline,Naltrexone,r-bPiDI
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