High-Throughput Single-Cell Sequencing of both TCR-β Alleles.

Tomonori Hosoya,Hongyang Li,Chia-Jui Ku,Qingqing Wu,Yuanfang Guan,James Douglas Engel

Journal of immunology (Baltimore, Md. : 1950)（2018）

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摘要

Allelic exclusion is a vital mechanism for the generation of monospecificity to foreign Ags in B and T lymphocytes. In this study, we developed a high-throughput barcoded method to simultaneously analyze the VDJ recombination status of both mouse TCR-β alleles in hundreds of single cells using next-generation sequencing.

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