A Cell Model Suitable for a High-Throughput Screening of Inhibitors of the Wnt/β-Catenin Pathway.

Marina Grimaldi,Abdelhay Boulahtouf,Corinne Prévostel,Alain Thierry,Patrick Balaguer,Philippe Blache

FRONTIERS IN PHARMACOLOGY（2018）

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摘要

A constitutive activation of the Wnt/beta-catenin pathway is an initiating event in colon carcinogenesis. We developed colon cancer cells models that highlight the non-selectivity of previously described inhibitors of the Wnt pathway and we propose our model as a suitable screening system for inhibitors of the pathway.

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关键词

cell models,Wnt/beta-catenin pathway,inhibitors,high-throughput screening,colorectal cancer

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