Cascade C–H Annulation Reaction of Benzaldehydes, Anilines, and Alkynes toward Dibenzo[a,f]quinolizinium Salts: Discovery of Photostable Mitochondrial Trackers at the Nanomolar Level
Organic Letters(2018)
Abstract
Fluorescent mitochondrial trackers with the dibenzo[a,f]quinolizinium core are unprecedentedly synthesized by a one-pot protocol starting from commercially available benzaldehydes, anilines, and alkynes through a rhodium(III)-catalyzed cascade C–H N- and C-annulation reaction. Among them, 5g is the most prominent and exhibits high specificity, high efficiency at nanomolar level, superior photostability, and low cytotoxicity.
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Key words
photostable mitochondrial trackers,benzaldehydes
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