Design, synthesis, structural characterization and in vitro evaluation of new 1,4-disubstituted-1,2,3-triazole derivatives against glioblastoma cells.

•Click Chemistry is the key step for obtaining 1,4 disubstituted-1,2,3-triazoles.•Compounds 9d and 10a presented higher potential antitumoral in glioblastoma cells.•Methylenoxy moiety is important for the pharmacological activity.•Compound 9d had the structural elucidation by single crystal X-ray diffraction.