HANR promotes hepatocellular carcinoma progression via miR-214/EZH2/TGF-β axis.

Yang Shi,Xiaohua Yang,Xiaofeng Xue,Ding Sun,Peng Cai,Qingwei Song,Bin Zhang,Lei Qin

Biochemical and Biophysical Research Communications（2018）

引用 14|浏览48

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摘要

•HANR directly targets miR-214.•MiR-214 inhibitor greatly rescues shHANR-induced tumor phenotypes of HCC cells.•HANR and miR-214 regulate EZH2 expression and TGF-β signaling.•EZH2 partially restores HCC phenotypes induced by HANR and miR-214.

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关键词

Hepatocellular carcinoma (HCC),Progression,HANR,miR-214,EZH2,TGF-β signaling

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