Amphiphilic block copolymer delivery of a DNA vaccine against Zika virus.

Peter Hraber,Steven Bradfute,Elizabeth Clarke,Chunyan Ye,Bruno Pitard

Vaccine（2018）

引用 19|浏览20

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摘要

•Amphiphilic block copolymers (ABC) can deliver DNA plasmid-encoded ZIKV antigens.•We tested antibody binding and neutralization against 3 divergent ZIKV isolates.•Full-length prM-E induced the greatest ELISA and neutralization responses tested.•10 or 50 µg i.m. prM-E ABC-DNA protected C57BL/6C anti-IFNAR mice from viremia.•ABC-DNA antigen delivery may simplify polyvalent cocktail immunogen development.

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关键词

Block copolymer,Zika virus,DNA vaccine,Flavivirus,Mouse model,Nanotechnology

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