The in vitro growth of a cord blood-derived cell population enriched for CD34 + cells is influenced by its cell cycle status and treatment with hydroxyurea.

Angélica Muñiz-Rivera-Cambas,Patricia Flores-Guzmán,Hector Mayani

Cytotherapy（2018）

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摘要

•Human hematopoietic cells are heterogeneous in terms of their cell cycle.•UCB cells in G0/G1 showed higher proliferation potential in vitro.•Treatment with HU induced an increase in the proportion of G1 cells.•HU also induced an increase in the frequency of CFCs.•HU favored the development of the E lineage.

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关键词

cell cycle,cytokines,differentiation,expansion,hematopoietic cells,hydroxyurea,in vitro growth,proliferation

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