A target screening method for detection of organic pollutants in fruits and vegetables by atmospheric pressure gas chromatography quadrupole-time-of-flight mass spectrometry combined with informatics platform.

•A high effective screening method for 104 organic contaminants in fruit and vegetables was developed.•Two different ionization mechanisms including charge-transfer and proton-transfer were optimized.•The screening detection limits (SDLs) of the analytes were validated.