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Prostaglandin E2 facilitates Hepatitis B virus replication by impairing CTL function

Xiaoyan Li,Tingting Xie,Lifen Gao,Chunhong Ma,Xiaoyun Yang,Xiaohong Liang

Molecular Immunology（2018）

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Abstract
•Chronic hepatitis B patients had high serum PGE2 level, related with viral load.•Exogenous PGE2 promotes HBV replication, while EP2/EP4 antagonists inhibit it.•Blockade of PGE2 signaling restores CD8 + T cells function in HBV infection milieu.
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Key words
PGE2,Chronic HBV infection,CD8+ T cells,Cytotoxicity,Cytokine secretion
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