Mucosal Bromodomain-Containing Protein 4 (BRD4) Mediates Aeroallergen-induced Inflammation and Remodeling.

Bing Tian,Koa Hosoki,Zhiqing Liu,Jun Yang,Yingxin Zhao,Hong Sun,Jia Zhou,Erik Rytting,Lata Kaphalia,William J Calhoun,Sanjiv Sur,Allan R Brasier

Journal of Allergy and Clinical Immunology（2019）

引用 39|浏览20

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摘要

NFκB-inducible BRD4 activity mediates cat dander-induced inflammation and remodeling. Therapeutic modulation of the NFκB-BRD4 pathway affects allergen-induced inflammation, epithelial cell-state changes, ECM production and expansion of the subepithelial myofibroblast population.

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关键词

Bromodomain-containing protein 4,epigenetics,myofibroblast,airway remodeling,aeroallergen,nuclear factor κB,histone acetyltransferase activity

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