Redox-responsive hyaluronic acid nanogels for hyperthermia- assisted chemotherapy to overcome multidrug resistance.
Carbohydrate Polymers（2019）
Abstract
•The nanogels with cystamine-crosslinking remain stable in the physiological condition.•The nanogels rapidly release the encapsulated DOX in the mimic intracellular glutathione condition.•The drug-resistance of MCF-7 ADR cells is reversed after hyperthermia treatment by AuNR-assisted NIR irradiation.•AuNRs loaded reduction-sensitive HA nanogels show excellent hyperthermia-assisted chemotherapy.
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Key words
Hyaluronic acid nanogels,Stimulus-responsive,NIR light,Cancer therapy
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