CHRFAM7A alters Binding to the Neuronal alpha-7 Nicotinic Acetylcholine Receptor.

Theresa Chan,Elliot Williams,Olga Cohen,Brian P Eliceiri,Andrew Baird,Todd W Costantini

Neuroscience Letters（2019）

引用 18|浏览12

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摘要

•CHRFAM7A is a uniquely-human gene that encodes a human-specific variant of the alpha-7 nicotinic acetylcholine receptor.•Forced expression of CHRFAM7A in an in vitro neuronal cell line decreases binding to the α7nAchR.•Alpha-bungarotoxin staining was decreased at the neuromuscular junction of CHRFAM7A transgenic mice.

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关键词

Duplicated nicotinic acetylcholine receptor,CHRFAM7A,Human-specific genes,α-bungarotoxin,Transgenic mouse,Neural α7nAchR

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