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Insights into hepatic and renal FXR/DDAH-1/eNOS pathway and its role in the potential benefit of rosuvastatin and silymarin in hepatic nephropathy.

Yosra M Magdy,Omnyah A El-Kharashi,Dalia A A El-Waseef,Enas S Nabih,Abeer A Abd El Samad

Experimental and Molecular Pathology（2018）

Cited 6|Views4
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Abstract
In conclusion, liver cirrhosis is associated with deterioration of renal functions. Silymarin and Rvs have a potential hepatorenal therapeutic benefit through simultaneous enhancement of FXR/DDAH-1/eNOS pathway in both organs.
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Key words
Cirrhosis,DDAH-1,FXR,Kidney,Rosuvastatin,Silymarin
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