Reduced intensity conditioning with fludarabine, melphalan, and total body irradiation for allogeneic hematopoietic cell transplantation: the effect of increasing melphalan dose on underlying disease and toxicity.

George L Chen,Theresa Hahn,Gregory E Wilding,Adrienne Groman,Alan Hutson,Yali Zhang, Usman Khan,Hong Liu,Maureen Ross,Barbara Bambach,Meghan Higman,Vishala Neppalli,Sheila Sait,AnneMarie W Block,Paul K Wallace,Anurag K Singh,Philip L McCarthy

Biology of Blood and Marrow Transplantation（2019）

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摘要

•Fludarabine, melphalan, and total body irradiation is an acceptable reduced-intensity conditioning regimen than can induce full donor chimerism.•Less robust patients with residual malignant disease may benefit most from fludarabine (160 mg/m2), melphalan (75 mg/m2), and total body irradiation.

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关键词

Reduced-intensity conditioning,Minimal residual disease,Fludarabine,Melphalan,Total body irradiation

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