Skewed ratio between type 1 and type 2 CALR mutations in Essential Thrombocytosis patients with concomitant JAK2 V617F mutation.
Experimental Hematology(2018)
摘要
•There is a dominant calreticulin (CALR) clone in essential thrombocytosis (ET) with low-frequency Janus kinase 2 (JAK2) V617F mutation.•CALR clone dictates the disease phenotype in ET with concomitant JAK2 V617F mutation.•Extended molecular diagnostic tests are warranted in low-frequency JAK2 V617F myeloproliferative neoplasm (MPN) patients.
更多查看译文
关键词
CALR,Essential thrombocytosis,JAK2 V617F,driver mutations,myeloproliferative neoplasms
AI 理解论文
溯源树
样例
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要