Prevalence and significance of T-wave inversion in children practicing sport: A prospective, 4-year follow-up study

•This study establishes the prevalence of TWI in a large cohort of children practising sport•This longitudinal study demonstrates that anterior TWI usually becomes positive by the age of 14 years•Conversely, children with infero-lateral TWI followed for 4 years did not demonstrate significant changes in the ECG pattern•Infero-lateral TWI should not be interpreted as physiologically related to age, development or training•This study support the concept that children with infero-lateral TWI should remain under strict clinical surveillance