Loss of Sfrp2 contributes to the neurological disorders related with morphine withdrawal via Wnt/β-catenin signaling.

•Wnt signaling could be activited after Morphine Withdrawal in rat nucleus accumbens.•Sfrp2 reversed the activation of Wnt signaling Induced by Morphine Withdrawal.•The morphine withdrawal-like symptoms in the SD rats could be attenuated by Sfrp2 injection.•Sfrp2 attenuated harm of dendritic spine after morphine withdrawal via Wnt signaling.