Skin permeation, biocompatibility and antitumor effect of chloroaluminum phthalocyanine associated to oleic acid in lipid nanoparticles

Ellen Denise P. Almeida, Lívia V. Dipieri,Fábia C. Rossetti,Juliana M. Marchetti,Maria Vitória L.B. Bentley,Rogéria de S. Nunes,Víctor Hugo V. Sarmento,Mário Ernesto G. Valerio,José Joatan Rodrigues Júnior,Monalisa M. Montalvão,Cristiane B. Correa,Ana Amélia M. Lira

Photodiagnosis and Photodynamic Therapy（2018）

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摘要

•Lipid nanoparticles increased the retained amount of drug into the skin.•The enhancing effect of penetration was also dependent on oleic acid concentration.•Lipid nanoparticles were biocompatible.•NLC presented potent antitumoral effect.•The presence of oleic acid in the NLC seems to potentialize the antitumoral effect.

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关键词

Chloroaluminum phthalocyanine,Lipid nanoparticles,Skin cancer,Drug delivery systems,Photodynamic therapy

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