Genome-wide association analysis suggests novel loci for Hashimoto’s thyroiditis

L. Brčić,A. Barić,S. Gračan, M. Brekalo,D. Kaličanin,I. Gunjača,V. Torlak Lovrić,S. Tokić, M. Radman,V. Škrabić,A. Miljković,I. Kolčić,M. Štefanić,L. Glavaš-Obrovac,D. Lessel,O. Polašek,T. Zemunik,M. Barbalić,A. Punda,V. Boraska Perica

Journal of Endocrinological Investigation（2019）

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摘要

Hashimoto’s thyroiditis (HT) is the most common form of autoimmune thyroid diseases. Current knowledge of HT genetics is limited, and not a single genome-wide association study (GWAS) focusing exclusively on HT has been performed to date. In order to decipher genetic determinants of HT, we performed the first GWAS followed by replication in a total of 1443 individuals from Croatia.

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关键词

Hashimoto’s thyroiditis,Autoimmunity,Hypothyroidism,GWAS,Genetics,Autoimmune thyroid disease

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